COVID-19 Response — Due to the evolving COVID-19 outbreak, particularly in Washington state, please be aware that our staffing and operations may be impacted for the next several weeks. We value your business and will respond to inquiries and issues as best we can and we appreciate your patience while we work through this ever changing situation. Updates

Trans Thrive

San Francisco Community Health Center (formally API Wellness)

(Transgender Health & Resource Initiative for Vital Empowerment)

Trans Thrive, which stands for Transgender Resource and Neighborhood Space (TRANS), and Transgender Health & Resource Initiative for Vital Empowerment (THRIVE) was the new incarnation of the transgender drop-in started by UCSF and transferred to Asian & Pacific Islander Wellness Center. As part of the newly branded SF Community Health Center, Trans Thrive now includes all services provided for the Trans/GNC community at SFCHC. Trans Thrive is more than a drop in center, it’s services for US, by US. We aim to create safe spaces, events and services for the entire Trans/GNC community. From case management and medical services (including Primary Care, HRT and Needle Exchange), to mental health and substance use support, to social groups and special events, to a drop in center (with snacks and refreshments, clothing closet and a computer lab), we have it all! We are trans services for US, by US. Together, we can get to health, wellness, and equality. Everyone is respected in this space! Who we serve - Transgender people of color - Transgender people living with or at risk for HIV - Transgender people with substance abuse issues - Homeless and marginally housed trans people - Trans people in jail & re-entering society - Transgender youth, gender variant and non-conforming - Transgender people new to Bay area - Anyone on the trans/GQ/GV spectrum Through our needle exchange and disposal program, people who inject drugs access sterile equipment and can safely dispose of bio-waste. Used needles are disposed of in accordance with established biohazardous waste standards. Needle exchange programs are intended to prevent the spread of the HIV virus and other blood-borne diseases, such as hepatitis B and C, among injection drug users and their sexual partners. Please call, email, or visit or social media pages to find out about the many other services we offer throughout the community.

  • Case Management/Coordinated Care
  • Community Trainings/Education
  • Drop-in center
  • Fentanyl Test Strips/Education
  • Hepatitis testing/Education
  • HIV testing/Education
  • LGBTQ Services
  • MAT Education/Referrals
  • Naloxone Distribution/Overdose Ed.
  • PrEP
  • Safe Sex Items
  • STI Testing   Treatment
  • Syringe Services
  • Wound Care Services

730 PolkSt
4th Floor
San Francisco, CA 94109 US


Needle Exchange Schedule:

Monday: 9:00am to 12:00pm

Tuesday: 2:00pm to 5:00pm

Wednesday: 9:00am to 12:00pm

Thursday: 1:00pm to 5:00pm

Friday: 1:00pm to 5:00pm

Saturday: 1:00pm to 5:00pm

Sunday: Closed


Drop-In Space:

Monday: Closed

Tuesday: 2:00pm to 5:00pm

Wednesday: Closed

Thursday: 1:00pm to 5:00pm

Friday: 1:00pm to 5:00pm

Saturday: 2:00pm to 5:00pm

Sunday: Closed



Main Office

730 Polk Street, 4th Floor

San Francisco, CA 94109


Tenderloin Clinic

726 Polk Street, 4th Floor

San Francisco, CA 94109


Castro Clinic

1800 Market Street, Suite #401

San Francisco, CA 94102

(415) 292-3400
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